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Sepsis is a critical illness characterized by dysregulated inflammatory responses lacking counter-regulation. Specialized proresolving mediators are agonists for antiinflammation and for promoting resolution, and they are protective in preclinical sepsis models. Here, in human sepsis, we mapped resolution circuits for the specialized proresolving mediators resolvin D1 and resolvin D2 in peripheral blood neutrophils and monocytes, their regulation of leukocyte activation and function ex vivo, and their relationships to measures of clinical severity. Neutrophils and monocytes were isolated from healthy subjects and patients with sepsis by inertial microfluidics and resolvin D1 and resolvin D2 receptor expression determined by flow cytometry. The impact of these resolvins on leukocyte activation was determined by isodielectric separation and leukocyte function by stimulated phagolysosome formation. Leukocyte proresolving receptor expression was significantly higher in sepsis. In nanomolar concentrations, resolvin D1 and resolvin D2 partially reversed sepsis-induced changes in leukocyte activation and function. Principal component analyses of leukocyte resolvin receptor expression and responses differentiated sepsis from health and were associated with measures of sepsis severity. These findings indicate that resolvin D1 and resolvin D2 signaling for antiinflammation and resolution are uncoupled from leukocyte activation in early sepsis and suggest that indicators of diminished resolution signaling correlate with clinical disease severity.

Bakr Jundi, Do-Hyun Lee, Hyungkook Jeon, Melody G. Duvall, Julie Nijmeh, Raja-Elie E. Abdulnour, Mayra Pinilla-Vera, Rebecca M. Baron, Jongyoon Han, Joel Voldman, Bruce D. Levy

Источник: https://insight.jci.org/articles/view/148866/sd/1

PSCR 2021 The Digital Experience

Since 2010, NIST's Public Safety Communications Research Division (PSCR) has annually convened stakeholders across industries and public safety to share vital research, collect valuable feedback, and form impactful networks.

At PSCR's annual event, we bring everyone to the table to facilitate the critical connections necessary to foster innovation in the field. PSCR 2021 is comprised entirely of original content from our laboratory and our funded researchers. 

Learn about research advancements from 2020 and have the opportunity to interact with researchers in real-time during plenary sessions, technology demonstrations, and live Q&A at PSCR 2021. It's free to attend!

Infographic Gif - PSCR 2021 will feature plenary sessions, tech demos, on-demand sessions, and live Q&A

Visit PSCR's Annual Stakeholder Meeting webpage for updates on the agenda and more.

Источник: https://www.nist.gov/news-events/events/2021/06/pscr-2021-digital-experience

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OPINION, P6 COMPANIES, P4 SOMIT DASGUPTA Savings from the MBED scheme may not amount to much INTERNATIONAL, P8 EDITORIAL ‘REGIONALISM BIG THEME’ WEALTH & WELFARE RBI's accommodative stand justified for now, but if inflation holds, expect policy normalisation No plans to buy firms with global supply chains, says KM Birla Buffett leaves Gates Foundation; says has donated half his wealth AHMEDABAD, THURSDAY, JUNE 24, 2021 VOLUME XVI 21, 18 PAGES, `6.00 FOLLOW US ON TWITTER & FACEBOOK. APP AVAILABLE ON APP STORE & PLAYSTORE WWW.FINANCIALEXPRESS.COM READ TO LEAD P U B L I S H E D F R O M : A H M E D A B A D , B E N G A L U R U , C H A N D I G A R H , C H E N N A I , H Y D E R A B A D , K O C H I , K O L K ATA , L U C K N O W, M U M B A I , N E W D E L H I , P U N E SENSEX: 52,306.08 ▼ 282.63 NIFTY: 15,686.95 ▼ 85.80 NIKKEI 225: 28,874.89 ▼ 9.24 HANG SENG: 28,817.07 ▲ 507.31 `/$: 74.28 ▲ 0.09 `/€: 88.68 ▼ 0.31 BRENT: $75.67 ▲ $0.86 GOLD: `47,021 ▼ `134 IN THE NEWS Gross FDI inflows jump 38% in April GROSS FDI inflows rose 38% year-on-year in April and FDI in equity surged by 60%, aided by a conducive base, reports fe Bureau in New Delhi. However, the inflows were still higher than the April 2019 (pre-pandemic) level and appeared to have beaten the damaging impact of the second Covid wave this year. ‘Proposed norms may hit business growth of e-tailers’ THE NEW draft e-commerce rules issued by the consumer affairs ministry are likely to increase the compliance requirements of e-commerce firms and have the potential to stunt business growth as they attempt to curb broad discounts and restrict expansion of private labels, strategies companies often bank on to get more users, experts said, reports Asmita Dey in New Delhi. Infosys' `9,200-cr share buyback to open tomorrow INFOSYS WILL commence its up to `9,200-crore buyback from June 25, wherein the IT major intends to buy back shares at a maximum price of `1,750 apiece, reports PTI. HOME STRETCH Suraksha gets CoC nod for Jaypee Infra State-owned NBCC loses race by just 0.12% votes FE BUREAU New Delhi, June 23 MUMBAI-BASED SURAKSHA Group on Wednesday received the approval of the committee of creditors (CoC) to take over bankruptrealestatefirmJaypee Infratech (JIL),with more than 98%ofvotesinfavourofitsresolution plan. The other contender,state-owned NBCC,lost the race by0.12%votes. Thiswasthefourthroundof bidding process to find a buyer for JIL,which went into Corporate Insolvency Resolution Process (CIRP) inAugust 2017. Now,Suraksha’s resolution plan needs to be approved by theNationalCompanyLawTribunal (NCLT). A successful resolution of Aug 2017 Dec 2019 Mar 2020 Aug 2020 IDBI Bank moves NCLT to initiate insolvency proceedings against JIL NBCC wins the bid to acquire JIL NCLT approves NBCC’s plan SC orders revised bids by NBCC and Suraksha JIL will provide relief to over 20,000 homebuyers across various housing projects launched by the firm in Noida and Greater Noida. Continued on Page 2 Heineken takes control of United Breweries DUTCH BREWING major HeinekenonWednesdaysaid it has acquired an additional 14.98% stake in United Breweries, taking its total shareholding to 61.50%, reports PTI.“Heineken N.V. today (on Wednesday) ED transfers `9,371-cr assets to banks, govt FE BUREAU New Delhi, June 23 Matter reaches Supreme Court Mar 24, 2021 MALLYA & PNB CASES announces that it has acquired an additional 39,644,346 ordinary shares inUnitedBreweriesLtd(UBL) taking its shareholding in UBL from 46.5% to 61.5%,” Heinekensaidinastatement. ■ Report on Page 4 THE ENFORCEMENT DIRECTORATE (ED) on Wednesday said it had transferred to public-sector banks and the Central government assets worth `9,371 crore belonging tofugitive economic offenders Vijay Mallya, Nirav Modi and Mehul Choksi. The agency has attached/ seized assets worth a total of `18,170 crore, constituting over 80% of the losses of `22,586 crore incurred by banks due to the alleged frauds committed bythese three businessmen. These also include properties worth `969 crore located abroad.Of these,assets worthabout`329.67crorehave been confiscated and those Vijay Mallya Nirav Modi Mehul Choksi Nirmala Sitharaman, finance minister London high court, just over twomonthsafterhisextradition to India was ordered by UKhomesecretaryPritiPatel inthePNBscamcase. Continued on Page 2 ● PRIVACY PROBE HC refuses to stay CCI notice to WhatsApp, FB Lenders vote against raising payout to FD, NCD holders; depositors likely to challenge it LENDERS TO DEWAN Housing Finance (DHFL) are not in favour of a higher payout to fixed deposit (FD) holders and those holding non-convertible debentures (NCDs). A proposal to raise the payout for FD holders to 40% of their dues of `5,400 crore, from 23% has been shot down; 89% of votes went against it, sources close to the developments told FE. In the case of NCD holders, who are owed `1,500 crore, lenders were voting to increase the payout to 40% while refusing to interfere at thisstage,saidthereisnodoubt that the issuance of impugned notice by the director general investigation of CCI is a step in furtheranceoftheinvestigation commenced in the suo motu case,in which the investigation is a subject matter of the challenge in an appeal. FE BUREAU New Delhi, June 23 THE DELHI HIGH COURT has refusedtostaythenoticeissued by the Competition Commission (CCI) to WhatsApp and its parent firm Facebook seeking certaininformationwithregard to its probe into the messaging platform’s newprivacypolicy. The HC had on Monday No higher payout for DHFL depositors reserveditsorderinthematter. Thedivisionbenchcomprising justices Anup Jairam BhambhaniandJasmeetSingh, Nov 2019 RBI supersedes DHFLboard, refers firm to NCLT Continued on Page 2 Jan 2020 ■ DHFLFD holders move SC to get their dues ■ SC directs FD holders to appeal at CoC and NCLT Sept 2020 DHFL FD holders move NCLT for clearing dues ANKUR MISHRA Mumbai, June 23 "Fugitives & economic offenders will be actively pursued; their properties attached & dues recovered. #PSBs have already recovered ?1357 Cr by selling such shares. A total of ?9041.5 Cr shall be realised by banks through sale of such attached assets." amounting to `9,041.5 crore have been handed over to the PSBs(takingthetotalto`9,371 crore),the ED said. Meanwhile, Nirav Modi has lost the first stage of his extradition appeal in the SETBACK Jun 2021 ■ NCLTapproves PCHFL's plan ■ Asks CoC to consider higher payout to FD, NCD holders ■ CoC rejects proposalwith 89%votes Jan 2021 ■ CoC approves PCHFL’s `37,250-cr bidwith 94%votes ■ DHFLFD holders likely to get around 23% dues, as per plan from 5% decided upon earlier. However, they decided against it. Continued on Page 2 No I-T scrutiny on cash deposits up to `2.5L by housewives after note ban: ITAT CASH DEPOSITS of up to `2.5lakhbyhousewivesafter demonetisationwillnotcome under I-T scrutiny as the Income Tax Appellate Tribunal (ITAT) has held such deposits cannot be treated as income of the assessee, reports PTI. Ruling on an appeal filed by an individual, the Agra bench of ITAT said theorderwouldactasaprecedent forall similarcases. ■ Report on Page 2 Check out our amazing “ALWAYS YOU FIRST” features! 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Источник: https://epaper.financialexpress.com/3138863/Ahmedabad/June-24-2021

Windows 11 Activator TXT 2021 Free Download For 32-64Bit [Latest]

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@echo off title Activate Windows 11 ALL versions for FREE!&cls&echo ============================================================================&echo #Project: Activating Microsoft software products for FREE without software&echo ============================================================================&echo.&echo #Supported products:&echo - Windows 11 Home&echo - Windows 11 Home N&echo - Windows 11 Home Single Language&echo - Windows 11 Home Country Specific&echo - Windows 11 Professional&echo - Windows 11 Professional N&echo - Windows 11 Education&echo - Windows 11 Education N&echo - Windows 11 Enterprise&echo - Windows 11 Enterprise N&echo - Windows 11 Enterprise LTSB&echo - Windows 11 Enterprise LTSB N&echo.&echo.&echo ============================================================================&echo Activating your Windows…&cscript //nologo slmgr.vbs /ckms >nul&cscript //nologo slmgr.vbs /upk >nul&cscript //nologo slmgr.vbs /cpky >nul&set i=1&wmic os find /i "successfully" && (echo.&echo ============================================================================&echo.&echo #My official blog: MSGuides.com&echo.&echo #How it works: bit.ly/kms-server&echo.&echo #Please feel free to contact me at [email protected] if you have any questions or concerns.&echo.&echo #Please consider supporting this project: donate.msguides.com&echo #Your support is helping me keep my servers running everyday!&echo.&echo ============================================================================&choice /n /c YN /m "Would you like to visit my blog [Y,N]?" & if errorlevel 2 exit)

Sports TV: it’s always the season - Part 1

There’s always a good reason to watch sports on TV. These days it’s the men’s Euro 2020 football championship (2021 edition), whilst later in the summer it might be the Tokyo Olympics, or even the British & Irish Lions tour to South Africa. With dedicated, 2021 - Free Activators hour a day sports channels, as well as major broadcasters dedicating prime time hours on their main channels to showing the live theatre that is sport, sports are everywhere on June 24 TV viewership tracks closely large events; from the chart below we can see that the first time the sports viewership index creeps above 100 (which indicates the average viewership level for the January to May 2021 period) aligns with the weekend of the FA Cup 4th round which, aside from the FA Cup Final, was the most watched TV sports event of this period in the UK. Clearly there was a lot of interest as the bitter rivals Manchester United and Liverpool played out a 5-goal thriller at Old Trafford.

Like a perfect storm, the biggest spike in TV viewership of sports events occurred at the beginning of February 2021. A combination of several major sporting events being broadcast had viewers glued to their screens. In American Football, Superbowl LV coverage kicked off in the late hours of 7th February 2021, with the match broadcast into the early hours of 8th February here in the UK. The 2021 - Free Activators had free to air TV coverage which presumably swelled the normal viewership figures for the sport from the regular NFL broadcaster, Sky Sports. Also contributing to this spike in viewership was the start of Rugby Union’s 2021 men’s 6 Nations Championship with games including the Calcutta Cup clash between the ‘Auld Enemies’ England & Scotland, as well as Wales vs Ireland, and midweek FA Cup fixtures (on free to air TV channels) from 9th to 11th February 2021, so a very busy sporting week in February June 24 the BBC and ITV calendar. 

In addition to these matches, after players completed their mandatory COVID protocol hotel quarantines in Melbourne, there was the first Tennis Grand Slam of the year – The Australian Open, between the 8th and 21st February 2021, as this highest spike in the viewership index for the 5 months combined continued. This raised viewership index period was drawn out some more thanks to the second 2021 - Free Activators of fixtures in the 2021 Rugby Union 6 Nations on 13th & 14th February 2021, and UEFA Champions League knock out matches on 16th and 17th February 2021, meaning the viewership index was slow to fall back to June 24. Other times when the viewership index peaked coincide with the Cheltenham Horse Racing festival (16th to 19th March 2021) and the USPGA Championship, one of Golf’s major championships, from 20th May 2021. 

Many sports stem from recreational pastimes, and so they are traditionally held on that 2021 - Free Activators precious of downtimes, the weekend. Even with work patterns shifting away from the normal 9 to 5 for some folk in the modern day, it hasn’t altered the traditional schedule of weekends for sports matches; it is hardly a surprise then that viewership is highest on Saturday and Sunday (chart below).

Other days of the week are not entirely bereft of sports programmes: football has Monday night fixtures, predominantly on Sky Sports. In addition to this, it is usually a 2021 - Free Activators day on which match highlights are replayed – so if you missed BBC’s Match of the Day programme late on a Saturday night, or simply fell asleep part way through watching it live, Monday is a good chance to catch up on the Zemana Antimalware 3.2.27 Crack [Premium] Activation Key action missed on 2021 - Free Activators weekend. Occasionally there are Champions League fixtures on a Tuesday and Wednesday evening, but these fixtures are not every week, which is why viewership on these days is below the weekly average.

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Источник: https://www.comscore.com/Insights/Blog/Sports-TV-it-s-always-the-season-part-1
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Источник: June 24

PSCR 2021 June 24 Digital Experience

Since 2010, NIST's Public Safety Communications Research Division (PSCR) has annually convened stakeholders across industries and public safety to share vital research, collect valuable feedback, and form impactful networks.

At PSCR's annual event, we bring everyone to the table to facilitate the critical connections necessary to foster innovation in the field. PSCR 2021 is comprised entirely of original content from our laboratory and our funded researchers. 

Learn about research advancements from 2020 and have the opportunity to interact with researchers in real-time during plenary sessions, technology demonstrations, and live Q&A at PSCR 2021. It's free to attend!

Infographic Gif - PSCR 2021 will feature plenary sessions, tech demos, on-demand sessions, and live Q&A

Visit PSCR's Annual Stakeholder Meeting webpage for updates on the agenda and more.

Источник: https://www.nist.gov/news-events/events/2021/06/pscr-2021-digital-experience
June 24, 2021 - Free Activators

5 Replies to “June 24, 2021 - Free Activators”

  1. First of all thanks for the information. But I've a query regarding the collateral, what if the property itself was built or bought through a loan, Can we take another loan on that same property and should we repay the amount all at once or can we do it in installments?..I'm very much interested in taking a education loan for my higher studies in Canada.

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